Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0052900 Intron-Exon-Intron chr8:141956063-141958822 chr8:140945964-140948723 2760 nt 0.3786
hsa_PTK2_0053000 Intron-Intron chr8:141956787-141957284 chr8:140946688-140947185 498 nt 0.3735
hsa_chr8_0163900 Intergenic-Intergenic chr8:141958721-141958887 chr8:140948622-140948788 167 nt 0.3653
hsa_PTK2_0053100 Intron-Exon-Intron chr8:141958765-141993741 chr8:140948666-140983642 250 nt 0.3400
hsa_PTK2_0053200 Intron-Intron chr8:141962263-141962447 chr8:140952164-140952348 185 nt 0.4324
hsa_chr8_0164000 Intergenic-Intergenic chr8:141962996-141963163 chr8:140952897-140953064 168 nt 0.3452
hsa_chr8_0164100 Intergenic-Intergenic chr8:141963304-141965587 chr8:140953205-140955488 2284 nt 0.4098
hsa_PTK2_0053300 Intron-Intron chr8:141964842-141993741 chr8:140954743-140983642 250 nt 0.3120
hsa_PTK2_0053400 Intron-Intron chr8:141967142-141977641 chr8:140957043-140967542 250 nt 0.2600
hsa_PTK2_0053500 Intron-Intron chr8:141970540-141972148 chr8:140960441-140962049 1609 nt 0.4295
Showing 551 to 560 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].