Basic Information

Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2 PPP1R71 FAK1 FAK FADK Protein Phosphatase 1 Regulatory Subunit 71 Focal Adhesion Kinase-Related Nonkinase PTK2 Protein Tyrosine Kinase 2 Focal Adhesion Kinase 1 EC 2.7.10.2 Pp125FAK P125FAK FADK 1 FRNK Protein Phosphatase 1, Regulatory Subunit 71 FAK-Related Non-Kinase Polypeptide Protein-Tyrosine Kinase 2 EC 2.7.10
Location (GRCh37)
8:141668481-142005154 UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
UCSC Genome Browser Search in Marker Scope
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PTK2_0053600 Intron-Intron chr8:141971041-141982451 chr8:140960942-140972352 250 nt 0.2960
hsa_PTK2_0053700 Intron-Intron chr8:141977020-141979993 chr8:140966921-140969894 2974 nt 0.3890
hsa_PTK2_0053800 Intron-Intron chr8:141979530-141980788 chr8:140969431-140970689 1259 nt 0.4400
hsa_PTK2_0053900 Intron-Intron chr8:141982595-141992502 chr8:140972496-140982403 250 nt 0.4400
hsa_chr8_0164200 Intergenic-Intergenic chr8:141984847-141994619 chr8:140974748-140984520 250 nt 0.3640
hsa_PTK2_0054100 Intron-Intron chr8:141989447-141989636 chr8:140979348-140979537 190 nt 0.3105
hsa_PTK2_0054200 Intron-Intron chr8:141990683-141990937 chr8:140980584-140980838 255 nt 0.4392
hsa_PTK2_0054300 Intron-Intron chr8:141990688-141990931 chr8:140980589-140980832 244 nt 0.4303
hsa_PTK2_0054400 Intron-Intron chr8:141990688-141990937 chr8:140980589-140980838 250 nt 0.4360
hsa_PTK2_0054500 Intron-Intron chr8:141991596-141992343 chr8:140981497-140982244 748 nt 0.3904
Showing 561 to 570 of 573 entries
Forensic Context

A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].