Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0022200 | Exon-Exon | chr8:141762331-141774389 | chr8:140752232-140764290 | 261 nt | 0.3831 |
| hsa_PTK2_0021300 | Exon-Exon | chr8:141762331-141810675 | chr8:140752232-140800576 | 442 nt | 0.4480 |
| hsa_PTK2_0021400 | Exon-Exon | chr8:141762331-141840625 | chr8:140752232-140830526 | 824 nt | 0.4260 |
| hsa_PTK2_0021500 | Exon-Exon | chr8:141762331-141900868 | chr8:140752232-140890769 | 1449 nt | 0.4320 |
| hsa_PTK2_0023500 | Exon-Exon | chr8:141771264-141772487 | chr8:140761165-140762388 | 119 nt | 0.3782 |
| hsa_PTK2_0023600 | Exon-Exon | chr8:141771264-141774389 | chr8:140761165-140764290 | 155 nt | 0.3742 |
| hsa_PTK2_0024700 | Exon-Exon | chr8:141771264-141780898 | chr8:140761165-140770799 | 250 nt | 0.3360 |
| hsa_PTK2_0025100 | Exon-Exon | chr8:141771264-141799625 | chr8:140761165-140789526 | 229 nt | 0.4192 |
| hsa_PTK2_0023700 | Exon-Exon | chr8:141771264-141810675 | chr8:140761165-140800576 | 357 nt | 0.4566 |
| hsa_PTK2_0023800 | Exon-Exon | chr8:141771264-141813749 | chr8:140761165-140803650 | 465 nt | 0.4516 |
Showing 51 to 60 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].