Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0023900 | Exon-Exon | chr8:141771264-141829119 | chr8:140761165-140819020 | 684 nt | 0.4357 |
| hsa_PTK2_0024000 | Exon-Exon | chr8:141771264-141840625 | chr8:140761165-140830526 | 739 nt | 0.4276 |
| hsa_PTK2_0024100 | Exon-Exon | chr8:141771264-141900868 | chr8:140761165-140890769 | 1364 nt | 0.4333 |
| hsa_PTK2_0029000 | Exon-Exon | chr8:141799573-141813749 | chr8:140789474-140803650 | 310 nt | 0.4903 |
| hsa_PTK2_0029100 | Exon-Exon | chr8:141799573-141829119 | chr8:140789474-140819020 | 529 nt | 0.4537 |
| hsa_PTK2_0029200 | Exon-Exon | chr8:141799573-141840625 | chr8:140789474-140830526 | 584 nt | 0.4418 |
| hsa_PTK2_0029300 | Exon-Exon | chr8:141799573-141856421 | chr8:140789474-140846322 | 647 nt | 0.4405 |
| hsa_PTK2_0029400 | Exon-Exon | chr8:141799573-141856777 | chr8:140789474-140846678 | 727 nt | 0.4360 |
| hsa_PTK2_0029500 | Exon-Exon | chr8:141799573-141874498 | chr8:140789474-140864399 | 815 nt | 0.4221 |
| hsa_PTK2_0029600 | Exon-Exon | chr8:141799573-141889736 | chr8:140789474-140879637 | 982 nt | 0.4409 |
Showing 61 to 70 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].