Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0029700 | Exon-Exon | chr8:141799573-141900868 | chr8:140789474-140890769 | 1209 nt | 0.4409 |
| hsa_PTK2_0031200 | Exon-Exon | chr8:141799573-141931231 | chr8:140789474-140921132 | 250 nt | 0.3720 |
| hsa_PTK2_0029800 | Exon-Exon | chr8:141799573-141935848 | chr8:140789474-140925749 | 1298 nt | 0.4461 |
| hsa_PTK2_0031700 | Exon-Exon | chr8:141803453-141813749 | chr8:140793354-140803650 | 257 nt | 0.4708 |
| hsa_PTK2_0031800 | Exon-Exon | chr8:141803453-141829119 | chr8:140793354-140819020 | 476 nt | 0.4391 |
| hsa_PTK2_0031900 | Exon-Exon | chr8:141803453-141874498 | chr8:140793354-140864399 | 762 nt | 0.4108 |
| hsa_PTK2_0032000 | Exon-Exon | chr8:141803453-141889736 | chr8:140793354-140879637 | 929 nt | 0.4327 |
| hsa_PTK2_0032100 | Exon-Exon | chr8:141803453-141900868 | chr8:140793354-140890769 | 1156 nt | 0.4343 |
| hsa_PTK2_0033100 | Intron-Intron | chr8:141809010-141809210 | chr8:140798911-140799111 | 201 nt | 0.3582 |
| hsa_PTK2_0033300 | Exon-Exon | chr8:141810558-141813749 | chr8:140800459-140803650 | 226 nt | 0.4735 |
Showing 71 to 80 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].