Basic Information
Symbol
circPTK2
RNA Class
circRNA
Alias
Protein Tyrosine Kinase 2
PPP1R71
FAK1
FAK
FADK
Protein Phosphatase 1 Regulatory Subunit 71
Focal Adhesion Kinase-Related Nonkinase
PTK2 Protein Tyrosine Kinase 2
Focal Adhesion Kinase 1
EC 2.7.10.2
Pp125FAK
P125FAK
FADK 1
FRNK
Protein Phosphatase 1, Regulatory Subunit 71
FAK-Related Non-Kinase Polypeptide
Protein-Tyrosine Kinase 2
EC 2.7.10
Location (GRCh37)
8:141668481-142005154
UCSC Genome Browser
Location (GRCh38)
8:140658382-140995055
Host gene
PTK2
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PTK2_0033400 | Exon-Exon | chr8:141810558-141829119 | chr8:140800459-140819020 | 445 nt | 0.4382 |
| hsa_PTK2_0033500 | Exon-Exon | chr8:141810558-141840625 | chr8:140800459-140830526 | 500 nt | 0.4260 |
| hsa_PTK2_0033600 | Exon-Exon | chr8:141810558-141856777 | chr8:140800459-140846678 | 643 nt | 0.4230 |
| hsa_PTK2_0033700 | Exon-Exon | chr8:141810558-141874498 | chr8:140800459-140864399 | 731 nt | 0.4090 |
| hsa_PTK2_0033800 | Exon-Exon | chr8:141810558-141889736 | chr8:140800459-140879637 | 898 nt | 0.4321 |
| hsa_PTK2_0033900 | Exon-Exon | chr8:141810558-141900868 | chr8:140800459-140890769 | 1125 nt | 0.4338 |
| hsa_PTK2_0035100 | Exon-Exon | chr8:141813642-141813749 | chr8:140803543-140803650 | 108 nt | 0.4352 |
| hsa_PTK2_0035200 | Exon-Exon | chr8:141813642-141900868 | chr8:140803543-140890769 | 1007 nt | 0.4250 |
| hsa_PTK2_0036300 | Exon-Exon | chr8:141828376-141829119 | chr8:140818277-140819020 | 219 nt | 0.4018 |
| hsa_PTK2_0036400 | Exon-Exon | chr8:141828376-141840625 | chr8:140818277-140830526 | 274 nt | 0.3869 |
Showing 81 to 90 of 573 entries
Forensic Context
A study in mice demonstrated that the circPTK2 is induced after oxygen-glucose deprivation and regulates microglia-induced hippocampal neuronal apoptosis via the miR-29b/SOCS-1-JAK2/STAT3-IL-1β axis [Huang et al. DOI:10.3390/cells11091381]. In a separate review, the circPTK2 was similarly noted to be induced after stroke, where it suppresses miR-29b, leading to JAK2/STAT3 activation, IL-1β production, and neuronal apoptosis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].