Forensic RNA Knowledge Base

Basic Information

Symbol

circRAPGEF6

RNA Class

circRNA

Alias

Rap Guanine Nucleotide Exchange Factor 6 RA-GEF-2 PDZ-GEF2 PDZGEF2 PDZ Domain Containing Guanine Nucleotide Exchange Factor (GEF) 2 PDZ Domain-Containing Guanine Nucleotide Exchange Factor 2 Rap Guanine Nucleotide Exchange Factor (GEF) 6 PDZ Domain-Containing Guanine Nucleotide Exchange Factor I KIA001LB RAGEF2

Location (GRCh37)

5:130759766-130970853 UCSC Genome Browser

Location (GRCh38)

5:131424073-131635160

UCSC Genome Browser Search in Marker Scope

Host gene

RAPGEF6

Host category

mRNA

Forensic tag(s)

Drug abuse diagnoses

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_RAPGEF6_0024400	Intron-Intron	chr5:130957796-130960027	chr5:131622103-131624334	2232 nt	0.3898
hsa_RAPGEF6_0024500	Intron-Intron	chr5:130958568-130960027	chr5:131622875-131624334	1460 nt	0.3842
hsa_CTC-432M15.3_0000100	Exon-Exon	chr5:130764595-130883883	chr5:131428902-131548190	144 nt	0.3750

Showing 251 to 253 of 253 entries

Forensic Context

A study in mice demonstrated that the circRAPGEF6 was differentially expressed in methamphetamine-treated primary cortical neurons, with RNA sequencing indicating up-regulation, though qRT-PCR validation showed an opposite expression pattern [Li et al. DOI:10.1016/J.Neulet.2019.02.032].