Basic Information
Symbol
circASTN1
RNA Class
circRNA
Alias
Astrotactin 1
ASTN
Astrotactin-1
Astrotactin
KIAA0289
Location (GRCh37)
1:176826120-177101054
UCSC Genome Browser
Location (GRCh38)
1:176856984-177131918
Host gene
ASTN1
Host category
mRNA
Forensic tag(s)
Wound age identification
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_ASTN1_0001000 | Exon-Exon | chr1:176837980-176857340 | chr1:176868844-176888204 | 707 nt | 0.5460 |
| hsa_ASTN1_0001100 | Exon-Exon | chr1:176837980-176863966 | chr1:176868844-176894830 | 976 nt | 0.5584 |
| hsa_ASTN1_0001200 | Exon-Exon | chr1:176837980-176903476 | chr1:176868844-176934340 | 1165 nt | 0.5536 |
| hsa_ASTN1_0001300 | Exon-Exon | chr1:176837980-176934373 | chr1:176868844-176965237 | 2124 nt | 0.5490 |
| hsa_ASTN1_0001900 | Exon-Exon | chr1:176845673-176863966 | chr1:176876537-176894830 | 792 nt | 0.5694 |
| hsa_chr1_0345300 | Intergenic-Intergenic | chr1:176848068-176848378 | chr1:176878932-176879242 | 311 nt | 0.5820 |
| hsa_ASTN1_0002100 | Exon-Exon | chr1:176851995-176853626 | chr1:176882859-176884490 | 288 nt | 0.5278 |
| hsa_ASTN1_0002200 | Exon-Exon | chr1:176851995-176863966 | chr1:176882859-176894830 | 691 nt | 0.5630 |
| hsa_chr1_0345700 | Intergenic-Intergenic | chr1:176881241-176882141 | chr1:176912105-176913005 | 901 nt | 0.3629 |
| hsa_ASTN1_0003600 | Intron-Exon-Intron | chr1:176900662-176905506 | chr1:176931526-176936370 | 250 nt | 0.3840 |
Showing 1 to 10 of 105 entries
Forensic Context
A study in mice and human-derived cells demonstrated that exosomes from adipose-derived stem cells expressing the circASTN1 promote SIRT1 expression and enhance endothelial progenitor cell function under hyperglycemic conditions, indicating a role in diabetic wound healing [Cheng et al. DOI:10.1093/burnst/tkae043]. In human postmortem brain studies, the linear transcript ASTN1 was identified as a target in a circRNA-miRNA-mRNA interaction network within the nucleus accumbens of subjects with alcohol dependence, where it was positively correlated with circRNA-406742 and negatively correlated with miR-1200 [Vornholt et al. DOI:10.1111/Adb.13071].