Basic Information
Symbol
circASTN1
RNA Class
circRNA
Alias
Astrotactin 1
ASTN
Astrotactin-1
Astrotactin
KIAA0289
Location (GRCh37)
1:176826120-177101054
UCSC Genome Browser
Location (GRCh38)
1:176856984-177131918
Host gene
ASTN1
Host category
mRNA
Forensic tag(s)
Wound age identification
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_ASTN1_0009300 | Intron-Exon-Intron | chr1:177030214-177101054 | chr1:177061078-177131918 | 250 nt | 0.4280 |
| hsa_chr1_0346100 | Intergenic-Intergenic | chr1:177035791-177036237 | chr1:177066655-177067101 | 447 nt | 0.4183 |
| hsa_ASTN1_0009500 | Intron-Intron | chr1:177098549-177100979 | chr1:177129413-177131843 | 2431 nt | 0.4118 |
| hsa_ASTN1_0009600 | Intron-Intron | chr1:177098978-177100979 | chr1:177129842-177131843 | 2002 nt | 0.4011 |
| hsa_ASTN1_0009700 | Intron-Intron | chr1:177098978-177101054 | chr1:177129842-177131918 | 2077 nt | 0.4049 |
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Forensic Context
A study in mice and human-derived cells demonstrated that exosomes from adipose-derived stem cells expressing the circASTN1 promote SIRT1 expression and enhance endothelial progenitor cell function under hyperglycemic conditions, indicating a role in diabetic wound healing [Cheng et al. DOI:10.1093/burnst/tkae043]. In human postmortem brain studies, the linear transcript ASTN1 was identified as a target in a circRNA-miRNA-mRNA interaction network within the nucleus accumbens of subjects with alcohol dependence, where it was positively correlated with circRNA-406742 and negatively correlated with miR-1200 [Vornholt et al. DOI:10.1111/Adb.13071].