Basic Information

Symbol
circSHPRH
RNA Class
circRNA
Alias
SNF2 Histone Linker PHD RING Helicase BA545I5.2 KIAA2023 SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase RING-Type E3 Ubiquitin Transferase SHPRH E3 Ubiquitin-Protein Ligase SHPRH FLJ90837 2610103K11Rik EC 2.3.2.27 EC 3.6.4.- RAD5
Location (GRCh37)
6:146106726-146285233 UCSC Genome Browser
Location (GRCh38)
6:145785590-145964097
UCSC Genome Browser Search in Marker Scope
Host gene
SHPRH
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_SHPRH_0012400 Intron-Intron chr6:146258667-146258821 chr6:145937531-145937685 155 nt 0.3484
hsa_SHPRH_0012500 Exon-Exon chr6:146261859-146264934 chr6:145940723-145943798 985 nt 0.4305
hsa_SHPRH_0012600 Exon-Exon chr6:146261859-146264938 chr6:145940723-145943802 79 nt 0.5063
hsa_SHPRH_0012700 Exon-Exon chr6:146261859-146266614 chr6:145940723-145945478 177 nt 0.4294
hsa_SHPRH_0012800 Exon-Exon chr6:146261859-146276490 chr6:145940723-145955354 79 nt 0.5063
hsa_SHPRH_0012900 Exon-Exon chr6:146262759-146275989 chr6:145941623-145954853 2021 nt 0.4112
hsa_SHPRH_0013000 Exon-Exon chr6:146262759-146276490 chr6:145941623-145955354 2522 nt 0.4076
hsa_SHPRH_0013100 Exon-Exon chr6:146264279-146273614 chr6:145943143-145952478 1605 nt 0.4093
hsa_SHPRH_0013200 Exon-Exon chr6:146264279-146276490 chr6:145943143-145955354 1937 nt 0.4125
hsa_chr6_0217900 Intergenic-Intergenic chr6:146264556-146276312 chr6:145943420-145955176 1815 nt 0.3879
Showing 131 to 140 of 154 entries
Forensic Context

A review of literature indicates that the circSHPRH is a tumor suppressor in brain cancer, specifically glioblastoma, where it is downregulated and its encoded SHPRH-146aa peptide inhibits glioma growth [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. A review of human studies indicates that the circSHPRH is downregulated in colorectal cancer tissues and is associated with metastasis and survival, while its overexpression inhibits proliferation and cell cycle progression [Lee et al. DOI:10.1016/j.biopha.2018.12.052].