Basic Information

Symbol
circSLC22A6
RNA Class
circRNA
Alias
Solute Carrier Family 22 Member 6 PAHT OAT1 ROAT1 Solute Carrier Family 22 (Organic Anion Transporter), Member 6 Renal Organic Anion Transporter 1 Organic Anion Transporter 1 PAH Transporter HROAT1 HOAT1 HPAHT Para-Aminohippurate Transporter
Location (GRCh37)
11:62697024-62751950 UCSC Genome Browser
Location (GRCh38)
11:62929552-62984478
UCSC Genome Browser Search in Marker Scope
Host gene
SLC22A6
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification Drug abuse diagnoses
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr11_0431000 Intergenic-Intergenic chr11:62732838-62742460 chr11:62965366-62974988 250 nt 0.4440
hsa_chr11_0431400 Intergenic-Intergenic chr11:62732858-62733017 chr11:62965386-62965545 160 nt 0.5063
hsa_SLC22A6_0000100 Exon-Exon chr11:62751416-62751950 chr11:62983944-62984478 238 nt 0.6218
Showing 11 to 13 of 13 entries
Forensic Context

A study in mice demonstrated that cocaine self-administration induces differential expression of 90 striatal circular RNAs, with 18 up-regulated and 72 down-regulated [Bu et al. DOI:10.1038/S41398-019-0527-1]. A study in humans demonstrated that circular transcripts of SLC22A6 are specifically expressed in urine and serve as a urine-specific biomarker for body fluid identification, with its inclusion in detection assays not impairing specificity [Liu et al. DOI:10.1007/s00414-019-02027-y]. circSLC22A6 harbors a low expression level of circular transcripts but maintains a high level of expression with a tissue-specific pattern, validating its forensic application for distinguishing urine from other forensically relevant body fluids [Song et al. DOI:10.1007/s00414-023-03091-1].