Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0002200 | Exon-Exon | chr2:40342713-40404995 | chr2:40115573-40177855 | 437 nt | 0.4897 |
| hsa_SLC8A1_0002300 | Exon-Exon | chr2:40342713-40405633 | chr2:40115573-40178493 | 107 nt | 0.4299 |
| hsa_SLC8A1_0003800 | Exon-Exon | chr2:40366541-40388004 | chr2:40139401-40160864 | 376 nt | 0.5000 |
| hsa_SLC8A1_0003900 | Exon-Exon | chr2:40366541-40392093 | chr2:40139401-40164953 | 376 nt | 0.5000 |
| hsa_SLC8A1_0004000 | Exon-Exon | chr2:40366541-40401982 | chr2:40139401-40174842 | 609 nt | 0.4893 |
| hsa_SLC8A1_0004100 | Exon-Exon | chr2:40366541-40402421 | chr2:40139401-40175281 | 21 nt | 0.4286 |
| hsa_SLC8A1_0004400 | Intron-Exon-Intron | chr2:40366541-40505907 | chr2:40139401-40278767 | 149 nt | 0.4698 |
| hsa_SLC8A1_0004500 | Intron-Exon-Intron | chr2:40366541-40505910 | chr2:40139401-40278770 | 276 nt | 0.5145 |
| hsa_SLC8A1_0003600 | Intron-Exon-Intron | chr2:40366541-40509351 | chr2:40139401-40282211 | 250 nt | 0.3400 |
| hsa_SLC8A1_0003700 | Intron-Exon-Intron | chr2:40366541-40512096 | chr2:40139401-40284956 | 250 nt | 0.3880 |
Showing 91 to 100 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].