Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0005800 | Exon-Exon | chr2:40387905-40392104 | chr2:40160765-40164964 | 100 nt | 0.4600 |
| hsa_SLC8A1_0005900 | Exon-Exon | chr2:40387905-40392124 | chr2:40160765-40164984 | 319 nt | 0.4765 |
| hsa_SLC8A1_0006000 | Exon-Exon | chr2:40387905-40402421 | chr2:40160765-40175281 | 121 nt | 0.4545 |
| hsa_SLC8A1_0005700 | Intron-Exon-Intron | chr2:40387905-40505907 | chr2:40160765-40278767 | 250 nt | 0.3600 |
| hsa_SLC8A1_0006300 | Intron-Exon-Intron | chr2:40387905-40505910 | chr2:40160765-40278770 | 106 nt | 0.4528 |
| hsa_SLC8A1_0006400 | Intron-Exon-Intron | chr2:40387905-40512096 | chr2:40160765-40284956 | 231 nt | 0.4805 |
| hsa_SLC8A1_0006500 | Intron-Exon-Intron | chr2:40387905-40549762 | chr2:40160765-40322622 | 100 nt | 0.4600 |
| hsa_SLC8A1_0006600 | Intron-Exon-Intron | chr2:40387905-40549814 | chr2:40160765-40322674 | 100 nt | 0.4600 |
| hsa_SLC8A1_0007000 | Exon-Exon | chr2:40391994-40404995 | chr2:40164854-40177855 | 235 nt | 0.4468 |
| hsa_SLC8A1_0006800 | Intron-Exon-Intron | chr2:40391994-40505907 | chr2:40164854-40278767 | 250 nt | 0.3760 |
Showing 101 to 110 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].