Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0007200 | Exon-Exon | chr2:40397421-40405633 | chr2:40170281-40178493 | 128 nt | 0.4297 |
| hsa_SLC8A1_0007400 | Exon-Exon | chr2:40401965-40402421 | chr2:40174825-40175281 | 39 nt | 0.4359 |
| hsa_SLC8A1_0007500 | Exon-Exon | chr2:40401965-40405633 | chr2:40174825-40178493 | 21 nt | 0.4286 |
| hsa_SLC8A1_0007900 | Intron-Exon-Intron | chr2:40402401-40404995 | chr2:40175261-40177855 | 830 nt | 0.3554 |
| hsa_SLC8A1_0008000 | Exon-Exon | chr2:40402401-40405633 | chr2:40175261-40178493 | 128 nt | 0.4297 |
| hsa_SLC8A1_0008400 | Intron-Intron | chr2:40466920-40512096 | chr2:40239780-40284956 | 250 nt | 0.3000 |
| hsa_SLC8A1_0008700 | Intron-Exon-Intron | chr2:40470512-40581037 | chr2:40243372-40353897 | 250 nt | 0.3960 |
| hsa_SLC8A1_0008900 | Intron-Exon-Intron | chr2:40470516-40576043 | chr2:40243376-40348903 | 100 nt | 0.4900 |
| hsa_SLC8A1_0009300 | Intron-Intron | chr2:40476070-40562546 | chr2:40248930-40335406 | 250 nt | 0.2920 |
| hsa_SLC8A1_0009400 | Intron-Exon | chr2:40476070-40657441 | chr2:40248930-40430301 | 151 nt | 0.4371 |
Showing 111 to 120 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].