Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0009500 | Intron-Intron | chr2:40484394-40509890 | chr2:40257254-40282750 | 250 nt | 0.3560 |
| hsa_chr2_0765800 | Intergenic-Intergenic | chr2:40485548-40486048 | chr2:40258408-40258908 | 501 nt | 0.4850 |
| hsa_SLC8A1_0009600 | Intron-Intron | chr2:40487365-40487535 | chr2:40260225-40260395 | 171 nt | 0.4327 |
| hsa_SLC8A1_0009700 | Intron-Intron | chr2:40487912-40488362 | chr2:40260772-40261222 | 451 nt | 0.4013 |
| hsa_SLC8A1_0009800 | Intron-Intron | chr2:40489411-40505350 | chr2:40262271-40278210 | 250 nt | 0.2680 |
| hsa_SLC8A1_0009900 | Intron-Intron | chr2:40490223-40492288 | chr2:40263083-40265148 | 2066 nt | 0.4022 |
| hsa_SLC8A1_0010400 | Intron-Intron | chr2:40490223-40505907 | chr2:40263083-40278767 | 149 nt | 0.4698 |
| hsa_SLC8A1_0010000 | Intron-Intron | chr2:40490223-40509351 | chr2:40263083-40282211 | 250 nt | 0.3120 |
| hsa_SLC8A1_0010100 | Intron-Intron | chr2:40490223-40512096 | chr2:40263083-40284956 | 250 nt | 0.3600 |
| hsa_SLC8A1_0010200 | Intron-Exon-Intron | chr2:40490223-40600861 | chr2:40263083-40373721 | 250 nt | 0.3400 |
Showing 121 to 130 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].