Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0010300 | Intron-Exon-Intron | chr2:40490223-40657444 | chr2:40263083-40430304 | 250 nt | 0.3520 |
| hsa_SLC8A1_0010500 | Intron-Intron | chr2:40492127-40494469 | chr2:40264987-40267329 | 2343 nt | 0.3850 |
| hsa_SLC8A1_0010600 | Intron-Intron | chr2:40492127-40496210 | chr2:40264987-40269070 | 250 nt | 0.3160 |
| hsa_SLC8A1_0010800 | Intron-Intron | chr2:40492127-40505910 | chr2:40264987-40278770 | 152 nt | 0.4671 |
| hsa_SLC8A1_0010700 | Intron-Intron | chr2:40492127-40512096 | chr2:40264987-40284956 | 250 nt | 0.3200 |
| hsa_SLC8A1_0010900 | Intron-Intron | chr2:40495374-40496065 | chr2:40268234-40268925 | 692 nt | 0.4017 |
| hsa_SLC8A1_0011000 | Intron-Intron | chr2:40497618-40497839 | chr2:40270478-40270699 | 222 nt | 0.4459 |
| hsa_chr2_0765900 | Intergenic-Intergenic | chr2:40497710-40500753 | chr2:40270570-40273613 | 250 nt | 0.3200 |
| hsa_SLC8A1_0011200 | Intron-Intron | chr2:40504016-40505910 | chr2:40276876-40278770 | 152 nt | 0.4671 |
| hsa_SLC8A1_0011100 | Intron-Intron | chr2:40504016-40509351 | chr2:40276876-40282211 | 250 nt | 0.2720 |
Showing 131 to 140 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].