Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0011400 | Intron-Intron | chr2:40504731-40505907 | chr2:40277591-40278767 | 1177 nt | 0.3713 |
| hsa_SLC8A1_0011500 | Intron-Intron | chr2:40504731-40505910 | chr2:40277591-40278770 | 212 nt | 0.4340 |
| hsa_SLC8A1_0011300 | Intron-Intron | chr2:40504731-40509890 | chr2:40277591-40282750 | 250 nt | 0.3040 |
| hsa_SLC8A1_0011600 | Intron-Intron | chr2:40505303-40505907 | chr2:40278163-40278767 | 605 nt | 0.4711 |
| hsa_SLC8A1_0011700 | Intron-Intron | chr2:40505303-40505910 | chr2:40278163-40278770 | 608 nt | 0.4704 |
| hsa_SLC8A1_0012500 | Intron-Intron | chr2:40505759-40509236 | chr2:40278619-40282096 | 192 nt | 0.4531 |
| hsa_SLC8A1_0012600 | Intron-Intron | chr2:40505759-40509351 | chr2:40278619-40282211 | 35 nt | 0.3714 |
| hsa_SLC8A1_0011800 | Intron-Intron | chr2:40505759-40509890 | chr2:40278619-40282750 | 250 nt | 0.3680 |
| hsa_SLC8A1_0011900 | Intron-Intron | chr2:40505759-40510469 | chr2:40278619-40283329 | 250 nt | 0.3400 |
| hsa_SLC8A1_0012700 | Intron-Intron | chr2:40505759-40512096 | chr2:40278619-40284956 | 157 nt | 0.4395 |
Showing 141 to 150 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].