Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0012000 | Intron-Intron | chr2:40505759-40512321 | chr2:40278619-40285181 | 250 nt | 0.3480 |
| hsa_SLC8A1_0012100 | Intron-Intron | chr2:40505759-40530723 | chr2:40278619-40303583 | 250 nt | 0.3520 |
| hsa_SLC8A1_0012200 | Intron-Intron | chr2:40505759-40549788 | chr2:40278619-40322648 | 250 nt | 0.4120 |
| hsa_SLC8A1_0012800 | Intron-Intron | chr2:40505759-40549814 | chr2:40278619-40322674 | 164 nt | 0.5061 |
| hsa_SLC8A1_0012300 | Intron-Exon | chr2:40505759-40657441 | chr2:40278619-40430301 | 250 nt | 0.3600 |
| hsa_SLC8A1_0012900 | Intron-Exon-Intron | chr2:40505759-40657444 | chr2:40278619-40430304 | 187 nt | 0.4011 |
| hsa_SLC8A1_0012400 | Intron-Exon-Intron | chr2:40505759-40680489 | chr2:40278619-40453349 | 250 nt | 0.4160 |
| hsa_chr2_0766000 | Intergenic-Intergenic | chr2:40507804-40508002 | chr2:40280664-40280862 | 199 nt | 0.3769 |
| hsa_chr2_0766100 | Intergenic-Intergenic | chr2:40507804-40508006 | chr2:40280664-40280866 | 203 nt | 0.3842 |
| hsa_chr2_0766200 | Intergenic-Intergenic | chr2:40507913-40508409 | chr2:40280773-40281269 | 497 nt | 0.3964 |
Showing 151 to 160 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].