Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0013100 | Intron-Exon | chr2:40511940-40657441 | chr2:40284800-40430301 | 184 nt | 0.4022 |
| hsa_SLC8A1_0013000 | Intron-Exon-Intron | chr2:40511940-40657444 | chr2:40284800-40430304 | 250 nt | 0.3560 |
| hsa_chr2_0766300 | Intergenic-Intergenic | chr2:40514422-40514747 | chr2:40287282-40287607 | 326 nt | 0.4325 |
| hsa_SLC8A1_0013200 | Intron-Intron | chr2:40515006-40516033 | chr2:40287866-40288893 | 1028 nt | 0.4066 |
| hsa_SLC8A1_0013300 | Intron-Intron | chr2:40515372-40515552 | chr2:40288232-40288412 | 181 nt | 0.3370 |
| hsa_chr2_0766400 | Intergenic-Intergenic | chr2:40517412-40518482 | chr2:40290272-40291342 | 1071 nt | 0.3436 |
| hsa_SLC8A1_0013400 | Intron-Intron | chr2:40524189-40549788 | chr2:40297049-40322648 | 98 nt | 0.5408 |
| hsa_SLC8A1_0013500 | Intron-Intron | chr2:40524577-40549788 | chr2:40297437-40322648 | 250 nt | 0.3400 |
| hsa_SLC8A1_0013600 | Intron-Intron | chr2:40524577-40561159 | chr2:40297437-40334019 | 250 nt | 0.3440 |
| hsa_SLC8A1_0013700 | Intron-Intron | chr2:40531860-40532056 | chr2:40304720-40304916 | 197 nt | 0.5025 |
Showing 161 to 170 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].