Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0013800 | Intron-Intron | chr2:40533914-40535337 | chr2:40306774-40308197 | 1424 nt | 0.3588 |
| hsa_chr2_0766500 | Intergenic-Intergenic | chr2:40534064-40534224 | chr2:40306924-40307084 | 161 nt | 0.3230 |
| hsa_chr2_0766600 | Intergenic-Intergenic | chr2:40534246-40535884 | chr2:40307106-40308744 | 1639 nt | 0.3722 |
| hsa_SLC8A1_0013900 | Intron-Intron | chr2:40537206-40549814 | chr2:40310066-40322674 | 250 nt | 0.3640 |
| hsa_chr2_0766700 | Intergenic-Intergenic | chr2:40537315-40537626 | chr2:40310175-40310486 | 312 nt | 0.4487 |
| hsa_chr2_0766800 | Intergenic-Intergenic | chr2:40537470-40537626 | chr2:40310330-40310486 | 157 nt | 0.4076 |
| hsa_SLC8A1_0014000 | Intron-Intron | chr2:40539112-40539280 | chr2:40311972-40312140 | 169 nt | 0.4201 |
| hsa_chr2_0766900 | Intergenic-Intergenic | chr2:40541288-40541619 | chr2:40314148-40314479 | 332 nt | 0.2922 |
| hsa_SLC8A1_0014100 | Intron-Intron | chr2:40541393-40542150 | chr2:40314253-40315010 | 758 nt | 0.2916 |
| hsa_SLC8A1_0014300 | Intron-Intron | chr2:40545018-40549814 | chr2:40317878-40322674 | 250 nt | 0.4280 |
Showing 171 to 180 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].