Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0014400 | Intron-Exon-Intron | chr2:40545018-40680489 | chr2:40317878-40453349 | 250 nt | 0.4240 |
| hsa_chr2_0767000 | Intergenic-Intergenic | chr2:40546493-40548548 | chr2:40319353-40321408 | 2056 nt | 0.3604 |
| hsa_SLC8A1_0014500 | Intron-Intron | chr2:40546607-40546774 | chr2:40319467-40319634 | 168 nt | 0.3929 |
| hsa_SLC8A1_0014600 | Intron-Exon | chr2:40549500-40657441 | chr2:40322360-40430301 | 250 nt | 0.3720 |
| hsa_SLC8A1_0014700 | Intron-Exon-Intron | chr2:40549500-40657444 | chr2:40322360-40430304 | 367 nt | 0.4441 |
| hsa_SLC8A1_0014800 | Intron-Intron | chr2:40549691-40562546 | chr2:40322551-40335406 | 250 nt | 0.3480 |
| hsa_SLC8A1_0015200 | Intron-Exon | chr2:40549691-40657441 | chr2:40322551-40430301 | 130 nt | 0.5385 |
| hsa_SLC8A1_0015300 | Intron-Exon-Intron | chr2:40549691-40657444 | chr2:40322551-40430304 | 130 nt | 0.5308 |
| hsa_SLC8A1_0014900 | Intron-Exon-Intron | chr2:40549691-40659437 | chr2:40322551-40432297 | 250 nt | 0.3520 |
| hsa_SLC8A1_0015400 | Intron-Exon-Intron | chr2:40549691-40673788 | chr2:40322551-40446648 | 124 nt | 0.5403 |
Showing 181 to 190 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].