Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0015500 | Intron-Exon-Intron | chr2:40549691-40680489 | chr2:40322551-40453349 | 124 nt | 0.5403 |
| hsa_SLC8A1_0015000 | Intron-Exon-Intron | chr2:40549691-40709870 | chr2:40322551-40482730 | 250 nt | 0.4000 |
| hsa_SLC8A1_0015600 | Intron-Exon-Intron | chr2:40549691-40710964 | chr2:40322551-40483824 | 124 nt | 0.5403 |
| hsa_SLC8A1_0015100 | Intron-Exon-Intron | chr2:40549691-40729232 | chr2:40322551-40502092 | 250 nt | 0.3800 |
| hsa_SLC8A1_0015700 | Intron-Exon-Intron | chr2:40549700-40657444 | chr2:40322560-40430304 | 250 nt | 0.3960 |
| hsa_SLC8A1_0015800 | Intron-Intron | chr2:40550962-40563945 | chr2:40323822-40336805 | 250 nt | 0.2240 |
| hsa_SLC8A1_0015900 | Intron-Intron | chr2:40554298-40555014 | chr2:40327158-40327874 | 717 nt | 0.3626 |
| hsa_chr2_0767100 | Intergenic-Intergenic | chr2:40555140-40555298 | chr2:40328000-40328158 | 159 nt | 0.3648 |
| hsa_chr2_0767200 | Intergenic-Intergenic | chr2:40560655-40561123 | chr2:40333515-40333983 | 469 nt | 0.3987 |
| hsa_SLC8A1_0016000 | Intron-Exon-Intron | chr2:40561063-40581037 | chr2:40333923-40353897 | 250 nt | 0.4240 |
Showing 191 to 200 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].