Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0016100 | Intron-Exon-Intron | chr2:40561063-40657444 | chr2:40333923-40430304 | 250 nt | 0.3880 |
| hsa_SLC8A1_0016200 | Intron-Exon-Intron | chr2:40561063-40680489 | chr2:40333923-40453349 | 189 nt | 0.5185 |
| hsa_chr2_0767300 | Intergenic-Intergenic | chr2:40562882-40563124 | chr2:40335742-40335984 | 243 nt | 0.3786 |
| hsa_chr2_0767400 | Intergenic-Intergenic | chr2:40563122-40563401 | chr2:40335982-40336261 | 280 nt | 0.4214 |
| hsa_SLC8A1_0016300 | Intron-Exon-Intron | chr2:40564166-40565245 | chr2:40337026-40338105 | 1080 nt | 0.3509 |
| hsa_SLC8A1_0016400 | Intron-Intron | chr2:40565006-40565254 | chr2:40337866-40338114 | 249 nt | 0.4016 |
| hsa_chr2_0767500 | Intergenic-Intergenic | chr2:40566866-40567910 | chr2:40339726-40340770 | 1045 nt | 0.4172 |
| hsa_SLC8A1_0016500 | Intron-Intron | chr2:40568978-40569131 | chr2:40341838-40341991 | 154 nt | 0.3247 |
| hsa_chr2_0767600 | Intergenic-Intergenic | chr2:40569932-40570134 | chr2:40342792-40342994 | 203 nt | 0.3645 |
| hsa_chr2_0767700 | Intergenic-Intergenic | chr2:40572020-40572569 | chr2:40344880-40345429 | 550 nt | 0.3945 |
Showing 201 to 210 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].