Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr2_0768500 | Intergenic-Intergenic | chr2:40598326-40598503 | chr2:40371186-40371363 | 178 nt | 0.3708 |
| hsa_chr2_0768600 | Intergenic-Intergenic | chr2:40598326-40599025 | chr2:40371186-40371885 | 700 nt | 0.4129 |
| hsa_SLC8A1_0018200 | Intron-Intron | chr2:40598810-40600399 | chr2:40371670-40373259 | 1590 nt | 0.3780 |
| hsa_SLC8A1_0018300 | Intron-Intron | chr2:40599485-40599759 | chr2:40372345-40372619 | 275 nt | 0.3818 |
| hsa_chr2_0768700 | Intergenic-Intergenic | chr2:40600307-40600449 | chr2:40373167-40373309 | 143 nt | 0.3147 |
| hsa_SLC8A1_0018400 | Intron-Exon-Intron | chr2:40600437-40657444 | chr2:40373297-40430304 | 250 nt | 0.3320 |
| hsa_chr2_0768800 | Intergenic-Intergenic | chr2:40601018-40601258 | chr2:40373878-40374118 | 241 nt | 0.4066 |
| hsa_chr2_0768900 | Intergenic-Intergenic | chr2:40601335-40601657 | chr2:40374195-40374517 | 323 nt | 0.3529 |
| hsa_chr2_0769000 | Intergenic-Intergenic | chr2:40601335-40601791 | chr2:40374195-40374651 | 457 nt | 0.3654 |
| hsa_chr2_0769100 | Intergenic-Intergenic | chr2:40602123-40603169 | chr2:40374983-40376029 | 1047 nt | 0.3763 |
Showing 231 to 240 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].