Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0018500 | Intron-Exon | chr2:40602404-40657441 | chr2:40375264-40430301 | 250 nt | 0.2880 |
| hsa_SLC8A1_0018600 | Intron-Intron | chr2:40602651-40603662 | chr2:40375511-40376522 | 1012 nt | 0.3854 |
| hsa_SLC8A1_0018700 | Intron-Intron | chr2:40604747-40604892 | chr2:40377607-40377752 | 146 nt | 0.3767 |
| hsa_SLC8A1_0018800 | Intron-Intron | chr2:40604747-40605425 | chr2:40377607-40378285 | 679 nt | 0.3667 |
| hsa_SLC8A1_0018900 | Intron-Exon | chr2:40604815-40657441 | chr2:40377675-40430301 | 250 nt | 0.3560 |
| hsa_SLC8A1_0019000 | Intron-Exon-Intron | chr2:40604815-40657444 | chr2:40377675-40430304 | 116 nt | 0.4741 |
| hsa_SLC8A1_0019100 | Intron-Exon-Intron | chr2:40604815-40659437 | chr2:40377675-40432297 | 71 nt | 0.3803 |
| hsa_SLC8A1_0019200 | Intron-Intron | chr2:40605188-40605549 | chr2:40378048-40378409 | 362 nt | 0.3950 |
| hsa_chr2_0769200 | Intergenic-Intergenic | chr2:40605286-40605515 | chr2:40378146-40378375 | 230 nt | 0.4043 |
| hsa_chr2_0769500 | Intergenic-Intergenic | chr2:40605691-40605853 | chr2:40378551-40378713 | 163 nt | 0.4294 |
Showing 241 to 250 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].