Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0019300 | Intron-Intron | chr2:40607928-40608196 | chr2:40380788-40381056 | 269 nt | 0.4387 |
| hsa_SLC8A1_0019400 | Intron-Intron | chr2:40608599-40609061 | chr2:40381459-40381921 | 463 nt | 0.3974 |
| hsa_SLC8A1_0019500 | Intron-Intron | chr2:40608751-40609061 | chr2:40381611-40381921 | 311 nt | 0.4116 |
| hsa_chr2_0769600 | Intergenic-Intergenic | chr2:40609183-40609494 | chr2:40382043-40382354 | 312 nt | 0.3878 |
| hsa_chr2_0769700 | Intergenic-Intergenic | chr2:40611623-40611827 | chr2:40384483-40384687 | 205 nt | 0.3024 |
| hsa_SLC8A1_0019600 | Intron-Exon-Intron | chr2:40612539-40657444 | chr2:40385399-40430304 | 187 nt | 0.4011 |
| hsa_SLC8A1_0019700 | Intron-Intron | chr2:40613363-40613536 | chr2:40386223-40386396 | 174 nt | 0.2989 |
| hsa_SLC8A1_0019800 | Intron-Intron | chr2:40614015-40614194 | chr2:40386875-40387054 | 180 nt | 0.3333 |
| hsa_SLC8A1_0019900 | Intron-Intron | chr2:40615724-40616126 | chr2:40388584-40388986 | 403 nt | 0.3002 |
| hsa_SLC8A1_0020000 | Intron-Intron | chr2:40616127-40616312 | chr2:40388987-40389172 | 186 nt | 0.2903 |
Showing 251 to 260 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].