Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr2_0769800 | Intergenic-Intergenic | chr2:40619341-40620153 | chr2:40392201-40393013 | 813 nt | 0.3493 |
| hsa_chr2_0769900 | Intergenic-Intergenic | chr2:40622631-40622980 | chr2:40395491-40395840 | 350 nt | 0.4057 |
| hsa_SLC8A1_0020100 | Intron-Intron | chr2:40623719-40623868 | chr2:40396579-40396728 | 150 nt | 0.2733 |
| hsa_SLC8A1_0020200 | Intron-Intron | chr2:40623719-40624299 | chr2:40396579-40397159 | 581 nt | 0.3408 |
| hsa_SLC8A1_0020300 | Intron-Intron | chr2:40624395-40629615 | chr2:40397255-40402475 | 250 nt | 0.2680 |
| hsa_SLC8A1_0020400 | Intron-Intron | chr2:40626219-40626438 | chr2:40399079-40399298 | 220 nt | 0.3727 |
| hsa_SLC8A1_0020500 | Intron-Intron | chr2:40627110-40627446 | chr2:40399970-40400306 | 337 nt | 0.4748 |
| hsa_chr2_0770000 | Intergenic-Intergenic | chr2:40627787-40628685 | chr2:40400647-40401545 | 899 nt | 0.4138 |
| hsa_SLC8A1_0020600 | Intron-Intron | chr2:40628366-40628520 | chr2:40401226-40401380 | 155 nt | 0.3935 |
| hsa_chr2_0770100 | Intergenic-Intergenic | chr2:40631930-40633697 | chr2:40404790-40406557 | 1768 nt | 0.3495 |
Showing 261 to 270 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].