Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr2_0770200 | Intergenic-Intergenic | chr2:40632336-40632813 | chr2:40405196-40405673 | 478 nt | 0.3515 |
| hsa_chr2_0770300 | Intergenic-Intergenic | chr2:40634091-40634348 | chr2:40406951-40407208 | 258 nt | 0.4922 |
| hsa_SLC8A1_0020700 | Intron-Intron | chr2:40636217-40636440 | chr2:40409077-40409300 | 224 nt | 0.3393 |
| hsa_SLC8A1_0020800 | Intron-Intron | chr2:40636602-40637341 | chr2:40409462-40410201 | 740 nt | 0.3905 |
| hsa_SLC8A1_0020900 | Intron-Intron | chr2:40637232-40639374 | chr2:40410092-40412234 | 2143 nt | 0.2982 |
| hsa_SLC8A1_0021000 | Intron-Intron | chr2:40639392-40639630 | chr2:40412252-40412490 | 239 nt | 0.3222 |
| hsa_SLC8A1_0021100 | Intron-Intron | chr2:40644143-40644447 | chr2:40417003-40417307 | 305 nt | 0.3410 |
| hsa_chr2_0770400 | Intergenic-Intergenic | chr2:40644203-40644344 | chr2:40417063-40417204 | 142 nt | 0.3028 |
| hsa_SLC8A1_0021200 | Intron-Intron | chr2:40644731-40646641 | chr2:40417591-40419501 | 1911 nt | 0.4108 |
| hsa_SLC8A1_0021300 | Intron-Exon-Intron | chr2:40648789-40657444 | chr2:40421649-40430304 | 143 nt | 0.4126 |
Showing 271 to 280 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].