Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0021400 | Intron-Exon | chr2:40653215-40657441 | chr2:40426075-40430301 | 162 nt | 0.3580 |
| hsa_SLC8A1_0021500 | Intron-Exon-Intron | chr2:40653215-40657444 | chr2:40426075-40430304 | 75 nt | 0.2933 |
| hsa_SLC8A1_0021600 | Intron-Intron | chr2:40654055-40654872 | chr2:40426915-40427732 | 818 nt | 0.3631 |
| hsa_chr2_0770500 | Intergenic-Intergenic | chr2:40654631-40655300 | chr2:40427491-40428160 | 670 nt | 0.3985 |
| hsa_SLC8A1_0022500 | Exon-Exon | chr2:40655613-40656640 | chr2:40428473-40429500 | 1028 nt | 0.4368 |
| hsa_SLC8A1_0022600 | Exon-Exon | chr2:40655613-40656666 | chr2:40428473-40429526 | 1054 nt | 0.4364 |
| hsa_SLC8A1_0022700 | Exon-Exon | chr2:40655613-40657107 | chr2:40428473-40429967 | 1495 nt | 0.4401 |
| hsa_SLC8A1_0022800 | Exon-Exon | chr2:40655613-40657110 | chr2:40428473-40429970 | 1498 nt | 0.4399 |
| hsa_SLC8A1_0022900 | Exon-Exon | chr2:40655613-40657308 | chr2:40428473-40430168 | 1696 nt | 0.4375 |
| hsa_SLC8A1_0023000 | Intron-Exon-Intron | chr2:40655613-40659437 | chr2:40428473-40432297 | 77 nt | 0.3636 |
Showing 281 to 290 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].