Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0023100 | Intron-Exon-Intron | chr2:40655613-40680489 | chr2:40428473-40453349 | 195 nt | 0.5077 |
| hsa_SLC8A1_0022000 | Intron-Exon-Intron | chr2:40655613-40684640 | chr2:40428473-40457500 | 250 nt | 0.3600 |
| hsa_SLC8A1_0022100 | Intron-Exon-Intron | chr2:40655613-40690490 | chr2:40428473-40463350 | 250 nt | 0.4040 |
| hsa_SLC8A1_0023200 | Intron-Exon-Intron | chr2:40655613-40698853 | chr2:40428473-40471713 | 63 nt | 0.3968 |
| hsa_SLC8A1_0023300 | Intron-Exon-Intron | chr2:40655613-40703550 | chr2:40428473-40476410 | 465 nt | 0.4559 |
| hsa_SLC8A1_0022200 | Intron-Exon-Intron | chr2:40655613-40706899 | chr2:40428473-40479759 | 250 nt | 0.3480 |
| hsa_SLC8A1_0023400 | Intron-Exon-Intron | chr2:40655613-40709870 | chr2:40428473-40482730 | 189 nt | 0.5185 |
| hsa_SLC8A1_0023500 | Intron-Exon-Intron | chr2:40655613-40710964 | chr2:40428473-40483824 | 151 nt | 0.4437 |
| hsa_SLC8A1_0023600 | Intron-Exon-Intron | chr2:40655613-40729228 | chr2:40428473-40502088 | 207 nt | 0.4106 |
| hsa_SLC8A1_0023700 | Intron-Exon-Intron | chr2:40655613-40729232 | chr2:40428473-40502092 | 188 nt | 0.4096 |
Showing 291 to 300 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].