Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0022300 | Exon-Exon | chr2:40655613-40739558 | chr2:40428473-40512418 | 1902 nt | 0.4385 |
| hsa_SLC8A1_0023800 | Intron-Exon-Intron | chr2:40655613-40784807 | chr2:40428473-40557667 | 106 nt | 0.4340 |
| hsa_SLC8A1_0022400 | Intron-Exon-Intron | chr2:40655613-40804952 | chr2:40428473-40577812 | 250 nt | 0.3560 |
| hsa_SLC8A1_0024200 | Exon-Intron | chr2:40655615-40659437 | chr2:40428475-40432297 | 71 nt | 0.3803 |
| hsa_SLC8A1_0024300 | Exon-Intron | chr2:40655615-40673788 | chr2:40428475-40446648 | 48 nt | 0.3958 |
| hsa_SLC8A1_0024100 | Exon-Intron | chr2:40655615-40680489 | chr2:40428475-40453349 | 250 nt | 0.4000 |
| hsa_SLC8A1_0024400 | Exon-Exon | chr2:40655674-40656079 | chr2:40428534-40428939 | 406 nt | 0.4335 |
| hsa_SLC8A1_0024600 | Exon-Exon | chr2:40655750-40656468 | chr2:40428610-40429328 | 719 nt | 0.4325 |
| hsa_chr2_0770600 | Intergenic-Intergenic | chr2:40655788-40656032 | chr2:40428648-40428892 | 245 nt | 0.4245 |
| hsa_chr2_0770700 | Intergenic-Intergenic | chr2:40656143-40656472 | chr2:40429003-40429332 | 330 nt | 0.4333 |
Showing 301 to 310 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].