Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0024700 | Exon-Exon | chr2:40656149-40656487 | chr2:40429009-40429347 | 339 nt | 0.4336 |
| hsa_SLC8A1_0024800 | Exon-Exon | chr2:40656224-40656487 | chr2:40429084-40429347 | 264 nt | 0.4394 |
| hsa_SLC8A1_0024900 | Exon-Exon | chr2:40656236-40656476 | chr2:40429096-40429336 | 241 nt | 0.4357 |
| hsa_SLC8A1_0025100 | Exon-Exon | chr2:40656488-40656626 | chr2:40429348-40429486 | 139 nt | 0.4388 |
| hsa_SLC8A1_0025200 | Exon-Exon | chr2:40656488-40656659 | chr2:40429348-40429519 | 172 nt | 0.4244 |
| hsa_SLC8A1_0025300 | Exon-Exon | chr2:40656488-40657146 | chr2:40429348-40430006 | 659 nt | 0.4416 |
| hsa_SLC8A1_0025400 | Exon-Exon | chr2:40656488-40657299 | chr2:40429348-40430159 | 812 nt | 0.4384 |
| hsa_SLC8A1_0025600 | Exon-Exon | chr2:40656539-40679080 | chr2:40429399-40451940 | 37 nt | 0.5135 |
| hsa_SLC8A1_0025700 | Exon-Exon | chr2:40656718-40657293 | chr2:40429578-40430153 | 576 nt | 0.4410 |
| hsa_SLC8A1_0025800 | Exon-Exon | chr2:40656718-40657299 | chr2:40429578-40430159 | 582 nt | 0.4416 |
Showing 311 to 320 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].