Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0025900 | Exon-Exon | chr2:40656728-40656927 | chr2:40429588-40429787 | 200 nt | 0.4600 |
| hsa_SLC8A1_0026000 | Exon-Exon | chr2:40656737-40657441 | chr2:40429597-40430301 | 705 nt | 0.4326 |
| hsa_chr2_0771000 | Intergenic-Intergenic | chr2:40656774-40657012 | chr2:40429634-40429872 | 239 nt | 0.4812 |
| hsa_chr2_0770800 | Intergenic-Intergenic | chr2:40656774-40680438 | chr2:40429634-40453298 | 250 nt | 0.3760 |
| hsa_chr2_0770900 | Intergenic-Intergenic | chr2:40656774-40680472 | chr2:40429634-40453332 | 250 nt | 0.4000 |
| hsa_chr2_0771100 | Intergenic-Intergenic | chr2:40656850-40657068 | chr2:40429710-40429928 | 219 nt | 0.4703 |
| hsa_SLC8A1_0026100 | Exon-Exon | chr2:40657247-40679080 | chr2:40430107-40451940 | 469 nt | 0.4200 |
| hsa_SLC8A1_0026200 | Exon-Exon | chr2:40657247-40739522 | chr2:40430107-40512382 | 232 nt | 0.4310 |
| hsa_SLC8A1_0026300 | Exon-Exon | chr2:40657258-40673788 | chr2:40430118-40446648 | 421 nt | 0.4109 |
| hsa_chr2_0771200 | Intergenic-Intergenic | chr2:40657349-40679142 | chr2:40430209-40452002 | 429 nt | 0.4406 |
Showing 321 to 330 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].