Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0026400 | Intron-Exon | chr2:40673311-40673657 | chr2:40446171-40446517 | 347 nt | 0.4063 |
| hsa_SLC8A1_0026500 | Exon-Exon | chr2:40673555-40673788 | chr2:40446415-40446648 | 234 nt | 0.4188 |
| hsa_SLC8A1_0026600 | Intron-Intron | chr2:40676939-40677190 | chr2:40449799-40450050 | 252 nt | 0.3492 |
| hsa_SLC8A1_0026700 | Intron-Intron | chr2:40685445-40685715 | chr2:40458305-40458575 | 271 nt | 0.4465 |
| hsa_chr2_0771500 | Intergenic-Intergenic | chr2:40691040-40692969 | chr2:40463900-40465829 | 1930 nt | 0.4021 |
| hsa_SLC8A1_0026800 | Intron-Intron | chr2:40695286-40696950 | chr2:40468146-40469810 | 1665 nt | 0.3279 |
| hsa_SLC8A1_0026900 | Intron-Intron | chr2:40695327-40696863 | chr2:40468187-40469723 | 1537 nt | 0.3338 |
| hsa_SLC8A1_0027000 | Intron-Intron | chr2:40698211-40698436 | chr2:40471071-40471296 | 226 nt | 0.4159 |
| hsa_SLC8A1_0027100 | Intron-Intron | chr2:40698791-40700357 | chr2:40471651-40473217 | 63 nt | 0.3968 |
| hsa_SLC8A1_0027200 | Intron-Intron | chr2:40700358-40700539 | chr2:40473218-40473399 | 182 nt | 0.3352 |
Showing 331 to 340 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].