Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr2_0771700 | Intergenic-Intergenic | chr2:40703827-40704423 | chr2:40476687-40477283 | 597 nt | 0.3367 |
| hsa_SLC8A1_0027300 | Intron-Intron | chr2:40704791-40704975 | chr2:40477651-40477835 | 185 nt | 0.3946 |
| hsa_SLC8A1_0027400 | Intron-Intron | chr2:40710177-40710964 | chr2:40483037-40483824 | 236 nt | 0.4661 |
| hsa_chr2_0771800 | Intergenic-Intergenic | chr2:40710554-40710789 | chr2:40483414-40483649 | 236 nt | 0.3856 |
| hsa_SLC8A1_0027500 | Intron-Intron | chr2:40736226-40736396 | chr2:40509086-40509256 | 171 nt | 0.3626 |
| hsa_chr2_0772000 | Intergenic-Intergenic | chr2:40745366-40767578 | chr2:40518226-40540438 | 250 nt | 0.3360 |
| hsa_chr2_0772100 | Intergenic-Intergenic | chr2:40757311-40767578 | chr2:40530171-40540438 | 250 nt | 0.3720 |
| hsa_chr2_0772200 | Intergenic-Intergenic | chr2:40760329-40767578 | chr2:40533189-40540438 | 358 nt | 0.4050 |
| hsa_SLC8A1_0027700 | Intron-Intron | chr2:40762099-40808138 | chr2:40534959-40580998 | 250 nt | 0.3440 |
| hsa_SLC8A1_0027800 | Intron-Intron | chr2:40784702-40787973 | chr2:40557562-40560833 | 250 nt | 0.3480 |
Showing 341 to 350 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].