Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0028100 | Intron-Intron | chr2:40784702-40808138 | chr2:40557562-40580998 | 61 nt | 0.5410 |
| hsa_SLC8A1_0027900 | Intron-Intron | chr2:40784702-40809199 | chr2:40557562-40582059 | 250 nt | 0.3200 |
| hsa_SLC8A1_0028200 | Intron-Intron | chr2:40787881-40809199 | chr2:40560741-40582059 | 250 nt | 0.3080 |
| hsa_SLC8A1_0028300 | Intron-Intron | chr2:40804692-40809199 | chr2:40577552-40582059 | 250 nt | 0.3000 |
| hsa_SLC8A1_0000300 | Exon-Exon | chr2:40325863-40326058 | chr2:40098723-40098918 | 196 nt | 0.2857 |
| hsa_SLC8A1_0000400 | Exon-Exon | chr2:40338321-40392124 | chr2:40111181-40164984 | 250 nt | 0.3520 |
| hsa_SLC8A1_0000600 | Exon-Intron | chr2:40338321-40397489 | chr2:40111181-40170349 | 300 nt | 0.4767 |
| hsa_SLC8A1_0000700 | Exon-Exon | chr2:40340698-40340944 | chr2:40113558-40113804 | 247 nt | 0.4170 |
| hsa_SLC8A1_0000800 | Exon-Exon | chr2:40341348-40341571 | chr2:40114208-40114431 | 224 nt | 0.4554 |
| hsa_SLC8A1_0001400 | Exon-Exon | chr2:40342512-40342737 | chr2:40115372-40115597 | 226 nt | 0.5531 |
Showing 351 to 360 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].