Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0021800 | Exon-Exon | chr2:40655613-40657444 | chr2:40428473-40430304 | 1832 nt | 0.4361 |
| hsa_SLC8A1_0021900 | Intron-Exon-Intron | chr2:40655613-40673788 | chr2:40428473-40446648 | 250 nt | 0.3640 |
| hsa_SLC8A1_0023900 | Exon-Exon | chr2:40655615-40657441 | chr2:40428475-40430301 | 1827 nt | 0.4362 |
| hsa_SLC8A1_0024000 | Exon-Exon | chr2:40655615-40657444 | chr2:40428475-40430304 | 1830 nt | 0.4361 |
| hsa_SLC8A1_0024500 | Exon-Exon | chr2:40655714-40656626 | chr2:40428574-40429486 | 913 nt | 0.4359 |
| hsa_SLC8A1_0025000 | Exon-Exon | chr2:40656488-40656605 | chr2:40429348-40429465 | 118 nt | 0.4153 |
| hsa_SLC8A1_0025500 | Exon-Exon | chr2:40656539-40656717 | chr2:40429399-40429577 | 179 nt | 0.4358 |
| hsa_SLC8A1_0027600 | Intron-Intron | chr2:40762099-40787973 | chr2:40534959-40560833 | 250 nt | 0.3240 |
| hsa_SLC8A1_0001000 | Exon-Exon | chr2:40342512-40405633 | chr2:40115372-40178493 | 995 nt | 0.4985 |
| hsa_SLC8A1_0003100 | Exon-Exon | chr2:40366541-40366816 | chr2:40139401-40139676 | 276 nt | 0.5145 |
Showing 41 to 50 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].