Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0003200 | Exon-Exon | chr2:40366541-40392124 | chr2:40139401-40164984 | 507 nt | 0.4990 |
| hsa_SLC8A1_0003300 | Exon-Exon | chr2:40366541-40397489 | chr2:40139401-40170349 | 576 nt | 0.4948 |
| hsa_SLC8A1_0003400 | Exon-Exon | chr2:40366541-40404995 | chr2:40139401-40177855 | 713 nt | 0.4741 |
| hsa_SLC8A1_0004200 | Exon-Exon | chr2:40366541-40405633 | chr2:40139401-40178493 | 737 nt | 0.4790 |
| hsa_SLC8A1_0005300 | Exon-Exon | chr2:40387905-40397489 | chr2:40160765-40170349 | 300 nt | 0.4767 |
| hsa_SLC8A1_0005400 | Exon-Exon | chr2:40387905-40404995 | chr2:40160765-40177855 | 437 nt | 0.4485 |
| hsa_SLC8A1_0006100 | Exon-Exon | chr2:40387905-40405633 | chr2:40160765-40178493 | 461 nt | 0.4577 |
| hsa_SLC8A1_0007100 | Exon-Exon | chr2:40391994-40405633 | chr2:40164854-40178493 | 361 nt | 0.4571 |
| hsa_SLC8A1_0007800 | Exon-Exon | chr2:40402401-40657444 | chr2:40175261-40430304 | 1960 nt | 0.4357 |
| hsa_SLC8A1_0014200 | Intron-Intron | chr2:40543761-40543898 | chr2:40316621-40316758 | 138 nt | 0.4058 |
Showing 51 to 60 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].