Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0016700 | Intron-Intron | chr2:40579321-40580634 | chr2:40352181-40353494 | 1314 nt | 0.4003 |
| hsa_SLC8A1_0016800 | Intron-Intron | chr2:40579529-40586672 | chr2:40352389-40359532 | 250 nt | 0.3320 |
| hsa_SLC8A1_0016900 | Intron-Intron | chr2:40580233-40580836 | chr2:40353093-40353696 | 604 nt | 0.4123 |
| hsa_SLC8A1_0017100 | Intron-Intron | chr2:40580622-40580836 | chr2:40353482-40353696 | 215 nt | 0.3767 |
| hsa_SLC8A1_0017200 | Intron-Intron | chr2:40580628-40580981 | chr2:40353488-40353841 | 354 nt | 0.4068 |
| hsa_chr2_0767900 | Intergenic-Intergenic | chr2:40580863-40581717 | chr2:40353723-40354577 | 855 nt | 0.4047 |
| hsa_chr2_0768000 | Intergenic-Intergenic | chr2:40581384-40581571 | chr2:40354244-40354431 | 188 nt | 0.3830 |
| hsa_chr2_0768100 | Intergenic-Intergenic | chr2:40581429-40581609 | chr2:40354289-40354469 | 181 nt | 0.4365 |
| hsa_SLC8A1_0017300 | Intron-Intron | chr2:40582012-40582521 | chr2:40354872-40355381 | 510 nt | 0.3824 |
| hsa_SLC8A1_0017400 | Intron-Intron | chr2:40582522-40583279 | chr2:40355382-40356139 | 758 nt | 0.4617 |
Showing 771 to 780 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].