Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0017500 | Intron-Intron | chr2:40583132-40583353 | chr2:40355992-40356213 | 222 nt | 0.4865 |
| hsa_chr2_0768200 | Intergenic-Intergenic | chr2:40585878-40586112 | chr2:40358738-40358972 | 235 nt | 0.4340 |
| hsa_SLC8A1_0017600 | Intron-Intron | chr2:40587879-40634819 | chr2:40360739-40407679 | 250 nt | 0.3800 |
| hsa_SLC8A1_0017700 | Intron-Intron | chr2:40591173-40591862 | chr2:40364033-40364722 | 690 nt | 0.2942 |
| hsa_SLC8A1_0017800 | Intron-Intron | chr2:40592339-40593302 | chr2:40365199-40366162 | 964 nt | 0.3693 |
| hsa_chr2_0768400 | Intergenic-Intergenic | chr2:40593582-40593769 | chr2:40366442-40366629 | 188 nt | 0.3351 |
| hsa_SLC8A1_0018000 | Intron-Intron | chr2:40596808-40604930 | chr2:40369668-40377790 | 250 nt | 0.3600 |
| hsa_SLC8A1_0018100 | Intron-Intron | chr2:40597159-40597385 | chr2:40370019-40370245 | 227 nt | 0.3744 |
| hsa_chr2_0768500 | Intergenic-Intergenic | chr2:40598326-40598503 | chr2:40371186-40371363 | 178 nt | 0.3708 |
| hsa_chr2_0768600 | Intergenic-Intergenic | chr2:40598326-40599025 | chr2:40371186-40371885 | 700 nt | 0.4129 |
Showing 781 to 790 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].