Basic Information
Symbol
circSLC8A1
RNA Class
circRNA
Alias
Solute Carrier Family 8 Member A1
NCX1
Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1
Solute Carrier Family 8 Member 1
Na(+)/Ca(2+)-Exchange Protein 1
Sodium/Calcium Exchanger 1
Na+/Ca++ Exchanger
Na+/Ca2+ Exchanger
CNC
Location (GRCh37)
2:40325863-40809199
UCSC Genome Browser
Location (GRCh38)
2:40098723-40582059
Host gene
SLC8A1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SLC8A1_0001400 | Exon-Exon | chr2:40342512-40342737 | chr2:40115372-40115597 | 226 nt | 0.5531 |
| hsa_SLC8A1_0001500 | Exon-Exon | chr2:40342512-40342769 | chr2:40115372-40115629 | 258 nt | 0.5543 |
| hsa_SLC8A1_0001100 | Exon-Exon | chr2:40342512-40366816 | chr2:40115372-40139676 | 534 nt | 0.5337 |
| hsa_SLC8A1_0001600 | Exon-Exon | chr2:40342512-40392124 | chr2:40115372-40164984 | 765 nt | 0.5176 |
| hsa_SLC8A1_0001700 | Exon-Exon | chr2:40342512-40401982 | chr2:40115372-40174842 | 867 nt | 0.5087 |
| hsa_SLC8A1_0001900 | Exon-Exon | chr2:40342512-40402421 | chr2:40115372-40175281 | 21 nt | 0.4286 |
| hsa_SLC8A1_0002000 | Exon-Exon | chr2:40342512-40404995 | chr2:40115372-40177855 | 110 nt | 0.4000 |
| hsa_SLC8A1_0001800 | Exon-Exon | chr2:40342512-40405619 | chr2:40115372-40178479 | 981 nt | 0.5015 |
| hsa_SLC8A1_0001300 | Exon-Intron | chr2:40342512-40505907 | chr2:40115372-40278767 | 250 nt | 0.3880 |
| hsa_SLC8A1_0002100 | Exon-Exon | chr2:40342713-40392124 | chr2:40115573-40164984 | 57 nt | 0.5614 |
Showing 81 to 90 of 912 entries
Forensic Context
A study in rats and H9c2 cells demonstrated that the circSLC8A1 is upregulated in ischemic heart disease models [Tian et al. DOI:10.1038/s41598-021-84056-5]. Furthermore, research in human peripheral blood confirmed the circSLC8A1 is significantly upregulated in myocardial infarction patients and exhibits high diagnostic value as a biomarker [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in mice demonstrated that the circSLC8A1 (mmu_circ_004295) is increased with ischemia time in the heart and promotes cardiomyocyte apoptosis by acting as an endogenous miR-133a-3p sponge [Tian et al. DOI:10.3390/molecules26041155].