Basic Information
Symbol
circSPINK5
RNA Class
circRNA
Alias
Serine Peptidase Inhibitor Kazal Type 5
LEKTI
VAKTI
LETKI
NETS
NS
Lympho-Epithelial Kazal-Type-Related Inhibitor
Lymphoepithelial Kazal-Type-Related Inhibitor
Serine Protease Inhibitor Kazal-Type 5
DKFZp686K19184
FLJ21544
FLJ97536
FLJ97596
FLJ99794
Serine Protease Inhibitor, Kazal Type 5
LEKTI Isoform
Location (GRCh37)
5:147391170-147499954
UCSC Genome Browser
Location (GRCh38)
5:148011607-148120391
Host gene
SPINK5
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
Forensic psychiatry evaluation
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SPINK5_0000600 | Exon-Exon | chr5:147449886-147488400 | chr5:148070323-148108837 | 1611 nt | 0.4233 |
| hsa_chr5_0228100 | Intergenic-Intergenic | chr5:147467228-147473305 | chr5:148087665-148093742 | 250 nt | 0.2920 |
| hsa_chr5_0228400 | Intergenic-Intergenic | chr5:147468917-147480160 | chr5:148089354-148100597 | 161 nt | 0.5093 |
| hsa_SPINK5_0000700 | Intron-Exon-Intron | chr5:147478797-147480695 | chr5:148099234-148101132 | 82 nt | 0.3902 |
| hsa_SPINK5_0000800 | Exon-Exon | chr5:147480918-147481471 | chr5:148101355-148101908 | 134 nt | 0.5075 |
| hsa_SPINK5_0000900 | Exon-Exon | chr5:147481373-147484563 | chr5:148101810-148105000 | 148 nt | 0.4797 |
| hsa_SPINK5_0001000 | Exon-Exon | chr5:147484515-147491458 | chr5:148104952-148111895 | 390 nt | 0.4462 |
| hsa_SPINK5_0001100 | Exon-Exon | chr5:147484515-147494052 | chr5:148104952-148114489 | 585 nt | 0.4444 |
| hsa_SPINK5_0001200 | Exon-Exon | chr5:147492431-147494052 | chr5:148112868-148114489 | 195 nt | 0.4410 |
| hsa_SPINK5_0001300 | Exon-Exon | chr5:147492431-147496029 | chr5:148112868-148116466 | 292 nt | 0.4486 |
Showing 11 to 20 of 21 entries
Forensic Context
A study in humans demonstrated that circSPINK5 is significantly decreased in the peripheral blood of Alzheimer's disease patients and may serve to distinguish them from other dementia cases [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans demonstrated that the circSPINK5 is expressed as both mRNA and circular RNA (circRNA) in vaginal secretions and was detected in all vaginal secretion samples using a multiplex assay [Liu et al. DOI:10.1016/J.Fsigen.2020.102312]. Its inclusion in biomarker detection did not impair specificity, though sporadic cross-reactivity in saliva was noted [Liu et al. DOI:10.1007/s00414-019-02027-y].