Basic Information
Symbol
circSPINK5
RNA Class
circRNA
Alias
Serine Peptidase Inhibitor Kazal Type 5
LEKTI
VAKTI
LETKI
NETS
NS
Lympho-Epithelial Kazal-Type-Related Inhibitor
Lymphoepithelial Kazal-Type-Related Inhibitor
Serine Protease Inhibitor Kazal-Type 5
DKFZp686K19184
FLJ21544
FLJ97536
FLJ97596
FLJ99794
Serine Protease Inhibitor, Kazal Type 5
LEKTI Isoform
Location (GRCh37)
5:147391170-147499954
UCSC Genome Browser
Location (GRCh38)
5:148011607-148120391
Host gene
SPINK5
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
Forensic psychiatry evaluation
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SPINK5_0001400 | Exon-Exon | chr5:147495933-147499954 | chr5:148116370-148120391 | 523 nt | 0.4340 |
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Forensic Context
A study in humans demonstrated that circSPINK5 is significantly decreased in the peripheral blood of Alzheimer's disease patients and may serve to distinguish them from other dementia cases [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans demonstrated that the circSPINK5 is expressed as both mRNA and circular RNA (circRNA) in vaginal secretions and was detected in all vaginal secretion samples using a multiplex assay [Liu et al. DOI:10.1016/J.Fsigen.2020.102312]. Its inclusion in biomarker detection did not impair specificity, though sporadic cross-reactivity in saliva was noted [Liu et al. DOI:10.1007/s00414-019-02027-y].