Basic Information
Symbol
circSRGAP1
RNA Class
circRNA
Alias
SLIT-ROBO Rho GTPase Activating Protein 1
ARHGAP13
KIAA1304
SLIT-ROBO Rho GTPase-Activating Protein 1
Rho GTPase-Activating Protein 13
SrGAP1
NMTC2
Location (GRCh37)
12:64474066-64521504
UCSC Genome Browser
Location (GRCh38)
12:64080286-64127724
Host gene
SRGAP1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_SRGAP1_0010000 | Exon-Exon | chr12:64474066-64521504 | chr12:64080286-64127724 | 1217 nt | 0.4692 |
Forensic Context
A review consolidating existing research indicates that the circSRGAP1 is a synaptically-enriched circular RNA abundant in the dendritic arbor, where it modulates structural changes at synapses during neuronal plasticity and development [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans demonstrated that circSRGAP1 is upregulated in the peripheral blood of coronary artery disease (CAD) patients, with an area under the curve (AUC) of 0.82, a sensitivity of 0.80, and a specificity of 0.867 for diagnostic discrimination [Tian et al. DOI:10.3390/molecules26041155].