Basic Information
Symbol
circTLK1
RNA Class
circRNA
Alias
Tousled Like Kinase 1
KIAA0137
PKU-BETA
Serine/Threonine-Protein Kinase Tousled-Like 1
Tousled-Like Kinase 1
EC 2.7.11.1
Serine Threonine Protein Kinase
SNARE Protein Kinase SNAK
EC 2.7.11
PKU-Beta
Location (GRCh37)
2:171847333-172087824
UCSC Genome Browser
Location (GRCh38)
2:170990823-171231314
Host gene
TLK1
Host category
mRNA
Forensic tag(s)
Cause of death analysis
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TLK1_0017300 | Intron-Intron | chr2:172009947-172012759 | chr2:171153437-171156249 | 267 nt | 0.4007 |
| hsa_TLK1_0017400 | Intron-Intron | chr2:172081499-172082012 | chr2:171224989-171225502 | 514 nt | 0.3482 |
Showing 371 to 372 of 372 entries
Forensic Context
A study in mice demonstrated that the circTLK1 is increased after stroke, where it functions as a miR-335-3p sponge to derepress TIPARP, thereby worsening ischemic injury [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans identified the circTLK1 as a circRNA involved in the septic acute kidney injury (SAKI) process [Ma et al. DOI:10.3389/fgene.2023.1209042].