Basic Information
Symbol
circTMEM165
RNA Class
circRNA
Alias
Transmembrane Protein 165
TPARL
SLC64A1
TMPT27
GDT1
Putative Divalent Cation/Proton Antiporter TMEM165
Transmembrane Protein TPARL
Transmembrane Protein PT27
TPA Regulated Locus
CDG2K
FT27
Location (GRCh37)
4:56225513-56310050
UCSC Genome Browser
Location (GRCh38)
4:55359346-55443883
Host gene
TMEM165
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TMEM165_0004400 | Exon-Exon | chr4:56283239-56291655 | chr4:55417072-55425488 | 289 nt | 0.3737 |
| hsa_TMEM165_0004500 | Exon-Exon | chr4:56283970-56284152 | chr4:55417803-55417985 | 183 nt | 0.3880 |
| hsa_TMEM165_0004600 | Exon-Exon | chr4:56283970-56290810 | chr4:55417803-55424643 | 289 nt | 0.4394 |
| hsa_TMEM165_0004800 | Intron-Intron | chr4:56284153-56284331 | chr4:55417986-55418164 | 179 nt | 0.4022 |
| hsa_chr4_0486500 | Intergenic-Intergenic | chr4:56285587-56285840 | chr4:55419420-55419673 | 254 nt | 0.4055 |
| hsa_TMEM165_0004900 | Intron-Intron | chr4:56287138-56288660 | chr4:55420971-55422493 | 1523 nt | 0.4642 |
| hsa_TMEM165_0005400 | Intron-Intron | chr4:56309578-56310050 | chr4:55443411-55443883 | 473 nt | 0.3594 |
Showing 51 to 57 of 57 entries
Forensic Context
A study in humans demonstrated that the circTMEM165 (hsa_circ_0001414) was significantly upregulated in the peripheral blood of myocardial infarction patients compared to healthy controls, as identified by RNA sequencing and validated by RT-qPCR [Li et al. DOI:10.3389/fcvm.2022.810257]. A study in human patients with ST-segment elevation myocardial infarction (STEMI) identified the circTMEM165 as a differentially expressed circular RNA in peripheral blood, a finding that was confirmed in an AC16 cell model [Wang et al. DOI:10.1515/med-2023-0807].