Forensic Context

A study in human bloodstained samples demonstrated that circTMEM56-RWDD3, a peripheral blood-specific circRNA, was successfully detected at all observation points when exposed to various environmental conditions mimicking crime scenes, including high temperatures, UV light, low temperatures, and disinfectants, exhibiting relative stability with unique degradation rates [Chen et al. DOI:10.1016/j.forsciint.2024.112148]. A study in human bloodstains demonstrated that circTMEM56-RWDD3 exhibited linear degradation over 120 days, with its relative expression levels showing a significant negative correlation with bloodstain age both indoors (r=-0.646) and outdoors (r=-0.88) [Wei et al. DOI:10.1016/j.forsciint.2022.111408].