Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0003800 | Exon-Exon | chr12:113705648-113722442 | chr12:113267843-113284637 | 57 nt | 0.5263 |
| hsa_TPCN1_0004300 | Exon-Exon | chr12:113706547-113711473 | chr12:113268742-113273668 | 230 nt | 0.5391 |
| hsa_TPCN1_0004500 | Intron-Exon-Intron | chr12:113707562-113707988 | chr12:113269757-113270183 | 427 nt | 0.5410 |
| hsa_TPCN1_0004600 | Exon-Exon | chr12:113707562-113711095 | chr12:113269757-113273290 | 183 nt | 0.5355 |
| hsa_TPCN1_0004700 | Exon-Exon | chr12:113707562-113722442 | chr12:113269757-113284637 | 206 nt | 0.5583 |
| hsa_chr12_0100200 | Intergenic-Intergenic | chr12:113707924-113713152 | chr12:113270119-113275347 | 250 nt | 0.4240 |
| hsa_TPCN1_0004800 | Intron-Exon-Intron | chr12:113709418-113711473 | chr12:113271613-113273668 | 1239 nt | 0.5278 |
| hsa_TPCN1_0005300 | Exon-Exon | chr12:113710463-113718000 | chr12:113272658-113280195 | 197 nt | 0.4873 |
| hsa_TPCN1_0005400 | Exon-Exon | chr12:113710463-113722576 | chr12:113272658-113284771 | 89 nt | 0.5056 |
| hsa_TPCN1_0005800 | Exon-Exon | chr12:113711037-113716640 | chr12:113273232-113278835 | 223 nt | 0.5157 |
Showing 61 to 70 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].