Basic Information
Symbol
circTPCN1
RNA Class
circRNA
Alias
Two Pore Segment Channel 1
TPC1
KIAA1169
Voltage-Dependent Calcium Channel Protein TPC1
Two Pore Calcium Channel Protein 1
Two Pore Channel Protein 1
FLJ20612
Two-Pore Channel 1, Homolog
Location (GRCh37)
12:113663049-113736389
UCSC Genome Browser
Location (GRCh38)
12:113225244-113298584
Host gene
TPCN1
Host category
mRNA
Forensic tag(s)
Mechanical injury analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TPCN1_0007000 | Exon-Exon | chr12:113724792-113728803 | chr12:113286987-113290998 | 53 nt | 0.4340 |
| hsa_TPCN1_0007300 | Exon-Exon | chr12:113725968-113726331 | chr12:113288163-113288526 | 104 nt | 0.5673 |
| hsa_chr12_0100600 | Intergenic-Intergenic | chr12:113726292-113726583 | chr12:113288487-113288778 | 292 nt | 0.6370 |
| hsa_TPCN1_0007400 | Exon-Exon | chr12:113726563-113729482 | chr12:113288758-113291677 | 96 nt | 0.5625 |
| hsa_chr12_0100700 | Intergenic-Intergenic | chr12:113729425-113729708 | chr12:113291620-113291903 | 88 nt | 0.5000 |
| hsa_chr12_0100800 | Intergenic-Intergenic | chr12:113729425-113729903 | chr12:113291620-113292098 | 283 nt | 0.5336 |
| hsa_chr12_0100900 | Intergenic-Intergenic | chr12:113732050-113733122 | chr12:113294245-113295317 | 1073 nt | 0.5098 |
| hsa_chr12_0101000 | Intergenic-Intergenic | chr12:113735328-113735728 | chr12:113297523-113297923 | 401 nt | 0.5536 |
| hsa_TPCN1_0007700 | Exon-Exon | chr12:113735445-113735705 | chr12:113297640-113297900 | 261 nt | 0.5134 |
| hsa_TPCN1_0007800 | Exon-Exon | chr12:113735825-113735983 | chr12:113298020-113298178 | 159 nt | 0.5849 |
Showing 81 to 90 of 90 entries
Forensic Context
A study in human traumatic brain injury (TBI) patients identified the circTPCN1 as a top up-regulated circular RNA (fold change 19.03) in brain injury tissues compared to adjacent contusion tissues, with its differential expression validated by qRT-PCR [Li et al. DOI:10.3389/fneur.2022.1086553]. The broader literature indicates that circular RNAs exhibit tissue-specific expression and can function as miRNA sponges, transcriptional regulators, and biomarkers for various conditions, including neurological disorders [Sema Misir et al. DOI:10.1038/s41418-022-00948-7].