Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0001700 | Exon-Exon | chr21:38458090-38462586 | chr21:37085790-37090286 | 1948 nt | 0.3789 |
| hsa_TTC3_0002000 | Exon-Exon | chr21:38459547-38461186 | chr21:37087247-37088886 | 437 nt | 0.3982 |
| hsa_TTC3_0002100 | Exon-Exon | chr21:38459547-38466390 | chr21:37087247-37094090 | 698 nt | 0.3639 |
| hsa_TTC3_0002200 | Exon-Exon | chr21:38459547-38468943 | chr21:37087247-37096643 | 856 nt | 0.3598 |
| hsa_TTC3_0002300 | Exon-Exon | chr21:38459547-38470460 | chr21:37087247-37098160 | 1102 nt | 0.3684 |
| hsa_TTC3_0004600 | Exon-Intron | chr21:38459547-38472048 | chr21:37087247-37099748 | 2690 nt | 0.3844 |
| hsa_TTC3_0002400 | Exon-Exon | chr21:38459547-38480746 | chr21:37087247-37108446 | 911 nt | 0.3655 |
| hsa_TTC3_0002500 | Exon-Exon | chr21:38459547-38501363 | chr21:37087247-37129063 | 1369 nt | 0.3733 |
| hsa_TTC3_0002600 | Exon-Exon | chr21:38459547-38519903 | chr21:37087247-37147603 | 2027 nt | 0.3823 |
| hsa_TTC3_0002700 | Exon-Exon | chr21:38459547-38525577 | chr21:37087247-37153277 | 2751 nt | 0.3759 |
Showing 1 to 10 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].